Plaque erosion is associated with myocardial infarction (MI) in about 30% of cases and may require a different management approach to plaque rupture. The investigators hypothesise that plaque erosion leads to higher levels of apoptotic circulating endothelial cells (CECs) compared to plaque rupture.

Among plaque erosion, white thrombus was seen in 55.8% (24/43) of patients and red thrombus in 27.9% (12/43) of patients. Compared to plaque erosion, plaque rupture more often showed positive remodeling (p=0.003) with a larger necrotic core area examined by virtual histology (VH)-IVUS, while negative remodeling was prominent in plaque erosion.

Apr 23, 2019 Plaque erosion seems to be on the rise as cause of coronary thrombosis, probably due to the changing of the cardiovascular risk profile and Plaque Rupture Versus Erosion: Is the Pathophysiology of ACS Changing? Page 2. Disclosures. Research Grants/Support.

Plaque erosion

Plaque erosion occurs without cap disruption where flowing blood comes into direct contact with intimal surface lacking endothelial cells. 1 In both clinical studies using intravascular imaging and autopsy data from subjects dying suddenly, plaque erosion is the second most common cause of coronary thrombus. Plaque Erosion In Vivo Diagnosis and Treatment Guided by Optical Coherence Tomography Sining Hu, MD,*y Haibo Jia, MD, P H D,*y Rocco Vergallo, MD,y Farhad Abtahian, MD, P H D,y Request PDF | Plaque Erosion | Plaque rupture and erosion are the two most common causes of acute coronary syndromes (ACS). Although plaque rupture has been well-characterized | Find, read and Among plaque erosion, white thrombus was seen in 55.8% (24/43) of patients and red thrombus in 27.9% (12/43) of patients. Compared to plaque erosion, plaque rupture more often showed positive remodeling (p=0.003) with a larger necrotic core area examined by virtual histology (VH)-IVUS, while negative remodeling was prominent in plaque erosion. Unlike the prominent fibrous cap inflammation described in ruptures, eroded surfaces contain fewer macrophages and T lymphocytes.

Thrombus was categorized as platelet-rich or fibrin-rich. Fig. 8.1 Angioscopic finding of plaque erosion and rupture.

Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion. Arterioscler Thromb Vasc Biol . 2002 ; 22 :1642–1648.

Plaque erosion in RCA. Images from an angiogram in a patient who presented to Emory University Hospital and underwent cardiac catheterization. In contrast, plaque erosion most frequently occurs on stenotic plaques in areas of elevated flow. This changes the behaviour of endothelial cells and primes the Nrf2 system, which under normal situations helps protect the endothelium.

In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. J Am Coll Cardiol. 2013;62(19):1748-1758.

Ruptur, sårbildning, erosion av ytan. - Exponerar lumen för mycket trombogena substanser (kollagen och vWF, samt TF som produceras av makrofager och Stabilized stannous fluoride dentifrice in relation to dental caries, dental erosion and dentin hypersensitivity: A systematic review. American Journal of Dentistry, effect of treating enamel with different fluorides against dental erosion in vitro.

Excoriation. rivsår. Vid MI ses tromb vid fissur (70%) eller erosion (30%) atherosclerotic plaques? Plaque. Plaque. Rupture. Fibrous,.
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Near a bifurcation is anatomically the most significant predictor of plaque erosion. Thrombus involved with plaque erosion occurs in fibrous or non-lipid plaques without TCFA and macrophages with larger lumen vessel.

In contrast with plaque rupture, the pathophysiological mechanisms leading to plaque erosion remain poorly understood.
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Plaque erosion is an important local substrate for acute coronary thrombosis in patients with acute myocardial infarction, especially women. Our data suggest that there are differences in plaque formation or local thrombogenic potential in men and women with coronary artery disease.

The characteristic histologic features are abundant surface smooth muscle cells and proteoglycans, and a small or absent lipid rich core. The mechanisms of plaque erosion are unclear, and there are no consistent risk factors, although patients are often smokers. Plaque erosion may involve a first step mediated by local flow perturbation around the plaque in the coronary artery, which activates the innate immune toll-like receptor 2, leading to endothelial cell death and desquamation on the plaque surface.